Stoichiometry Program

Antibodies Against Membrane Protein Targets. As the pharmaceutical and biotech industries increasingly shift attention to biologics, much more attention is being paid to the prospect of membrane bound proteins as drug targets for antibodies and other protein scaffolds. For the large GPCR and ion channel target classes, biologics offer improved selectivity, an alternative for targets with known function that have not been amenable to small molecule drugs and the potential for using antibodies for the targeted delivery of therapeutics. However, for the field to advance, fundamental challenges in optimizing antigen quality and presentation, discovery methodologies, protein engineering and target identification must be resolved. This two part meeting provides a forum in which discovery biologists and protein engineers can come together to discuss next generation strategies and technologies that will allow antibody and alternate scaffold based therapeutics directed against these target families to advance into the clinic and beyond. Part Two The second conference, Structural Analysis, Characterization and Biopharmaceutical Development, explores new developments in structural biology and characterization assays used to support research against these challenging targets. This segment then examines progress in biotherapeutic development for GPCR, ion channel and transporter targets, with emphasis on overcoming challenges that have impacted the progress of past programs from development into the clinic. Final Agenda. Day 1 Day 2 Download Brochure. Wednesday, September 2. Conference Registration Open. Plenary Keynote Programclick here for details2 0. Refreshment Break in the Exhibit Hall with Poster Viewing. Welcome Remarks. Kent Simmons, Senior Conference Director, Cambridge Healthtech Institute. Chairpersons Opening Remarks. Dana Lord, Ph. D., Scientist, Sanofi Genzyme. KEYNOTE PRESENTATION State of the Science Tools for Structural Studies of Membrane Protein Targets. Thomas P. Sakmar, M. D., Richard M. Isabel P. Furlaud Professor, Laboratory of Chemical Biology Signal Transduction, The Rockefeller University Guest Professor, Karolinska Institute, Sweden. Novel methods, including time resolved X ray crystallography and high resolution molecular microscopy, often in combination with computational molecular dynamics simulations, are providing new insights about how membrane proteins really work. Developing biotherapeutics or small molecule drugs increasingly requires a multidisciplinary team effort to apply both new and traditional approaches to enhance pre clinical drug discovery efforts. Norton Ghost 12 Dos Version Of Lemmings'>Norton Ghost 12 Dos Version Of Lemmings. My goal is to provide an up to date critical summary of some new single molecule drug discovery tools. Large Scale Determination of Previously Unsolved Protein Structures Using Evolutionary Information from Metagenomic Sequence Data. Microsoft Vsa Obsolete. Sergey Ovchinnikov, Biologist, Baker Lab, Institute for Protein Design, University of Washington. Despite decades of work by structural biologists, there are still 5. Chemical reaction A process in which one or more substances, the reactants, are converted to one or more different substances, the products. Substances are either. Learn more about Chemistry Electronics, Biology, Microscopy Microscope, Amateur Radio, Photography, Radio Astronomy, Science, Home Learning and much more. We show that Rosetta structure prediction guided by residue residue contacts inferred from evolutionary information can accurately model proteins that belong to large families and that metagenome sequence data more than triple the number of protein families with sufficient sequences for accurate modeling. We generate models for 6. Computational Approaches to Antibody Engineering Advances in Modeling Liabilities. Christopher Negron, Ph. D., Senior Scientist, Schrdinger. Experimental techniques for discovering and optimizing antibodies with high affinity for a target have matured significantly. Fad6%2Fad653585-0609-4e81-95d3-58c4f9ddfb1f%2FphpiUW8G3.png' alt='Stoichiometry Program' title='Stoichiometry Program' />The Advanced Laboratory for Iontronic, Electronic and Nanomaterials ALIEN, led by Prof. D. Venkataraman, works on developing next generation materials for energy. The Civil Engineering Technology program at Algonquin College is a continuation of the Construction Engineering Technician program that allows graduates to pursue a. Study CHM150 General Chemistry I from University of Phoenix. View chm150 course topics and additional information. Dental Admission Test DAT 2017 Program Guide Read this Guide before submitting an application to test. At the time of application, you will be required to acknowledge. Stoichiometry Program' title='Stoichiometry Program' />However, the discovery and optimization of other drug like properties for antibodies remain challenging. Thus we describe computational workflows for identifying and removing liabilities such as aggregation propensity. Beyond this, we will discuss tools such as FEP, that can be used to maintain affinity and stability during the optimization of other drug like properties. Refreshment Break in the Exhibit Hall with Poster Viewing. Structure and Function of Chemokine Receptors. Martin Gustavsson, Ph. D., Post Doctoral Scholar, Handel Lab, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego. Chemokines are small, secreted proteins that interact with G protein coupled chemokine receptors in the cell membrane to drive cell migration and regulate a number of physiological processes. I will present our recent advances in understanding the structure, dynamics and function of chemokine receptors using x ray crystallography in combination with other biophysical and biochemical methods. Implementation and Application of Internal Cryo EM Lab for Support of Membrane Protein Research. Claudio Ciferri, Ph. D., Senior Scientist, Structural Biology, Genentech. Recent breakthroughs in cryo EM enabled atomic resolution structure determinations of several proteins including integral membrane proteins. At Genentech, we are establishing a state of the art cryo EM group to support small and large molecule drug discovery as well as basic research projects, with a particular focus on membrane proteins. In my talk, I will present the workflow we established to enable structure determination of our membrane protein targets in lipid bi layer environment. The Peptidisc for Trapping Membrane Proteins in Water Soluble Nanoparticles. Franck Duong, Ph. D., Professor, Biochemistry, University of British Columbia, Canada. Purified membrane proteins are insoluble without detergents, adding difficulty to antibody production and protein crystallisation. We present the Peptidisc for their facile capture into water soluble nanoparticles. Unlike the Nanodisc, which requires scaffold proteins of different lengths and precise amounts of exogenous lipids, the peptidisc just requires a short bi helical peptide and no lipids. We show the effective reconstitition of 5 different membrane protein systems using on column, on gel, and on beads methods. Close of Day. 6 3. Dinner Short Course Registration. Click here for details on short courses offered. Day 1 Day 2 Download Brochure. Thursday, September 2. High Resolution Floral Vector Free Download on this page. Registration Open. Interactive Breakout Discussion Groups with Continental Breakfast. Grab a cup of coffee and join a breakout discussion group. These are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic. Details on the topics and moderators are below. Please click here for full details on all breakouts. Emerging Methods for Expression and Reconstitution of GPCRs. Moderator Scott R. Prosser, Ph. D., Professor, Chemistry and Biochemistry, University of Toronto, Canada E. GPCRs. Yeast opportunities and developments. Purification, extraction, reconstitution. Micelles versus HDLs versus liposomes. Biosynthetic labeling and the use of isotopes. Insect cells HEK cells efficiencies and opportunities. Characterization of Antibodies Against Membrane Proteins. Moderator Joseph Rucker, Ph. D., Vice President, Research and Development, Integral Molecular, Inc. Affinity and Kinetics Useful approaches for characterizing antibody binding interpreting complex binding.